Di Santo completed his feat with a penalty before the break and Huntelaar, who otherwise had a quiet evening, claimed his 49th goal in UEFA competitions in the 84th after a fine pass from Leroy Sane.Also in Group K, Sparta Prague defeated APOEL 2-0.
Stephan El Shaarawy scored late for Monaco to snatch a 1-1 draw against Tottenham. Azerbaijani side Qarabag defeated Anderlecht 1-0 in the other Group J match.
Also, Athletic Bilbao lost 2-1 at AZ Alkmaar and Partizan Belgrade won 3-1 at Augsburg in Group L.
Giuseppe Rossi rounded off the scoring as Fiorentina won 4-0 at Belenenses to move second in Group I, where FC Basel stayed top with a 2-0 home win over Lech Poznan.
Another Italian side, Lazio, won 3-2 at home against Saint-Etienne, which ended the game with nine players. Lazio moved top of Group G with its first win, ahead of Dnipro Dnipropetrovsk on goal difference. The Ukrainian side lost 1-0 at Rosenborg.
In Group H, Lokomotiv Moscow claimed its second win from two games with a 2-0 victory over Albanian side Skenderbeu Korce, and Besiktas drew 1-1 with visiting Sporting CP.
Liverpool, Borussia Dortmund, Marseille, Ajax and Celtic were all in action later Thursday.
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