Held scoreless in the first two rounds, Ronaldo exploded with a blistering hat trick in the seventh, 17th and 20th minutes before setting up Karim Benzema to make it 4-0 before halftime in Barcelona.
The Portugal forward added two more goals in the second half.
Ronaldo also scored five goals in a 9-1 win over Granada on April 5.
Madrid secured its second win — to go with one draw— before Barcelona visits Atletico Madrid later in a clash between the last two league champions.
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